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Portincasa P, Wang DQ

The mechanism by which Mounjaro may influence appetite-related thoughts relates to its pharmacological action on appetite-regulating pathways: GLP-1 receptor activation slows gastric emptying, prolonging feelings of fullness and reducing hunger signals sent to the brain GIP receptor activation may enhance satiety and improve glucose metabolism Central nervous system effects include action on hypothalamic appetite centres, potentially reducing the neurological drive to eat Clinical trial data demonstrate that tirzepatide produces substantial weight loss in specific populations

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Retatrutide produces roughly 60% more weight loss than semaglutide in clinical trials