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As patients lose weight on GLP-1 therapy, reflux may improve despite the gastric-slowing effect, creating a paradoxical clinical picture that requires individualized assessment

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REDEFINE1 (Phase 3): Over 3,400 adults with obesity or overweight (no T2DM) lost 22.7% of baseline body weight after 68 weeks, versus 12% with cagrilintide alone, 16% with semaglutide alone, and 2.3% on placebo

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This then reduces to a neutral ascorbate molecule [14]

This process not only supports physical endurance but also helps reduce mental fatigue and improve focus