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In most individuals, GLP-1RA-induced body weight loss is achieved within the first 36 months of treatment, and in most patients, the body weight loss is maintained if treatment is continued, while discontinuation will lead to some regain of lost body weight

10.1007/s12035-014-9012-2 179 LeeS.-H.ChoiS.-M.YangE

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An extended-release formulation of exenatide was subsequently developed for once-weekly administration by incorporating exenatide into an extended-release microsphere formulation [19]