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The BLA is supported by 96-week data from the randomized, placebo-controlled phase 3 GlucoGene clinical trial (NCT05139316)

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Wang L, Wang A, Guo H, Zhang Z, Wang S, Pei T, Liu Z, Yang D, Liu Y, Ruan C (2021) Neuroprotective effects of long-term metformin preconditioning on rats with ischemic brain injuries

Short-term effects of acute inhibition of the angiotensin-converting enzyme on the renin-angiotensin system and plasma atrial natriuretic peptide in healthy dogs fed a low-sodium diet versus a normal sodium diet, Journal of Veterinary Medicine Series A 41 (1-10): 121-127

Research shows this mechanism gives insights into fat metabolism, muscle health and NAD+ biology