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Daniels L, et al

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The early manifestation of diabetic cardiomyopathy is isolated diastolic dysfunction, which transitions to systolic dysfunction as the disease progresses

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Sueyoshi, T., and Negishi, M

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Discontinuation due to adverse events runs approximately 4-7% across studies, which is comparable to other GLP-1 receptor agonists

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65 VanderpasJBContemprBDualeNLGoossensWBebeNThorpeRet al

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Patient Eligibility and Safety Considerations Contrave requires careful patient selection due to bupropion's neuropsychiatric risk profile

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