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doi:10.1097/grf.0000000000000155 Creasy SA, Lang W, Tate DF, Davis KK, Jakicic JM

The rapid onset without psychomimetic effects places it in a different category from ketamine, another fast-acting antidepressant approach that carries significant abuse potential

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[8] [9] The net effect of combining these agents on glycaemic control is unpredictable and could result in dysglycaemia particularly hyperglycaemia or worsening insulin resistance especially in individuals with pre-existing impaired glucose tolerance or type 2 diabetes