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5.1.2 Effects on pancreatic -cell glucagon release In addition to their insulinotropic effects on -cells, both GIP and GLP-1 play a role in regulating glucagon secretion of pancreatic -cells, with GIP increasing and GLP-1 suppressing glucagon secretion, both in a glucose-dependent manner

Limit Alcohol Alcohol can worsen both nausea and reflux while on GLP-1 therapy

Semaglutide improves it through glucose-dependent insulin secretion

This makes it easier to stick to a healthy diet and avoid overeating

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[3] However, the precise contribution of each receptor pathway to gastrointestinal tolerability in a triple agonist has not been fully characterised in humans, and this attribution should be regarded as informed by class-effect data rather than confirmed mechanism