If you have diabetes and are taking insulin or sulfonylureas alongside GLP-1 therapy, be alert for hypoglycaemia symptoms and discuss dose adjustments with your healthcare team
GLP-1-based therapies and the exocrine pancreas: more light, or just more heat
SNAC facilitates absorption through a combination of mechanisms: local pH buffering, protection from pepsin-mediated degradation, and enhancement of transcellular transport ( 6.3 Near-boundary cases: oral octreotide and other partial successes Oral octreotide (Mycapssa) represents a partial success that illustrates boundary constraints
This slow increase helps reduce side effects
We found that cisplatin treatment caused a decrease in mitochondrial biogenesis (PGC-1, NRF-1, TFAM, mtDNA, ND1), mitochondrial mass (Porin and Citrate synthase activity) and fusion index (MFN2, Drp1), together with changes in the expression of autophagy-related genes (AKT/FoxO pathway, Atg1, Beclin1, LC3AII, p62) and enhanced ROS production (PRX III, MnSOD)
As a result, it has no denominator or comparison group to tease out whether adverse events like suicidal thoughts are the result of a drug or something else
