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LPS activates TLR4 on microglia, leading to the release of inflammatory cytokines and chemokines (322), and promotes neuronal apoptosis and endothelial cells damage (323, 324)

In a healthy system: insulin rises mainly after eating carbohydrates (sugars and starches) as glucose is cleared, insulin falls again protein causes only a modest insulin rise fat causes very little insulin release This rise-and-fall pattern allows the body to switch between storing and burning energy

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Phentermine is typically prescribed as part of a comprehensive weight loss program that includes dietary changes, exercise, and behavior modification

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