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In place of stability testing, 503A compounding pharmacies often rely on the following to establish the beyond-use date: Manufacturer recommendations Published clinical literature Limits set by the USP However, variances in formulation, container/closure system, and storage conditions between the medication the compounding pharmacy is altering and the reference drug that has undergone stability testing can result in an inaccurate beyond use date

Due to the evidence from these trials, in May 2022, tirzepatide received FDA approval to improve glycemic control in patients with T2D as an adjunct to diet and exercise [37]

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For research reference only.

Burton GJ, Jauniaux E