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12 January 2019

A phase II/III study assessed the efficacy of PD-1 inhibitor sintilimab plus IBI305, a bevacizumab (VEGF monoclonal antibody) biosimilar, versus sorafenib, as a first-line therapy for unresectable HBV-associated HCC

Lastly we identified a POAG-associated intronic variant on chromosome 9 which encodes UBAP2 , a gene associated with the neurodegenerative disease amyotrophic lateral sclerosis 44 ,in which astrocytes play a role in both ALS disease and in changes to the optic nerve head in glaucoma 45

MicroRNA206 contributes to the progression of steroidinduced avascular necrosis of the femoral head by inducing osteoblast apoptosis by suppressing programmed cell death 4

This may be due to its action as an aid in fat metabolism, which may make it useful in weight loss and obesity management

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