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GLP-1 receptor agonism has been studied extensively in the context of glucose-stimulated insulin secretion, glucagon suppression, gastric emptying modulation, and appetite-regulating circuits in the central nervous system

Daver N, Kantarjian H, DeBose K, Jabbour E, Borthakur G, Pemmaraju N, Garcia-Manero G, Kornlbau S, Wierda W, Burger J, DiNardo C, Ravandi F, Cortes J, Andreeff M , Konopleva M

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After initiation of Saxenda observe patients carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)