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While these approaches remain important, a growing body of scientific research suggests that autism may also involve deeper biological mechanisms including mitochondrial dysfunction, chronic neuroinflammation, immune imbalance, and disruption of the gutbrain axis

This dysfunction may contribute to impaired gut motility and constipation

doi:10.1016/j.ejphar.2003.11.038 14

It establishes the clinical context in which downstream metabolic adaptation, altered nutrient intake, and long-term physiological tradeoffs should be interpreted