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doi: 10.1016/j.freeradbiomed.2007.10.054

Pretreatment with metformin for 2 h significantly enhanced incretin-induced cAMP production by 1.7-fold in the presence of 5.5 mM glucose, but this was not metformin dose-dependent

In this pilot study, patients were classified as responders and non-responders according to the magnitude of HbA1c reduction after GLP-1 RA therapy

GLP-1 agonists, such as Trulicity (dulaglutide), also provide cardiovascular protection and are FDA-approved to reduce the risk of major cardiovascular events in diabetes patients with heart disease or related risk factors

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