reports research grants and/or personal fees from AstraZeneca/Bristol-Myers Squibb, Boehringer Ingelheim, Dexcom, Eli Lilly, GlaxoSmithKline, Insulet Corp, Janssen Pharmaceuticals, Lexicon Pharmaceuticals, Medtronic, Merck & Co Inc, Population Health Research Institute, Roche Pharma, Sanofi, and Takeda
Braffett, B
May increase the risk of hypoglycemia when combined with insulin or other anti-diabetic drugs
There is also some evidence that tirzepatide affects gastric emptying less aggressively than semaglutide at equivalent therapeutic levels, though direct comparison data during exercise is limited
Veru press release, 28 May 2025: Veru Reports Positive Safety Results from Phase 2b QUALITY Study: Enobosarm Added to Semaglutide Led to Greater Fat Loss, Preservation of Muscle, and Fewer Gastrointestinal Side Effects Compared to Semaglutide Alone Rivus Pharmaceuticals press release, 30 September 2024: Regeneron press release, 2 June 2025: Interim Results from Ongoing Phase 2 COURAGE Trial Confirm Potential to Improve the Quality of Semaglutide (GLP-1 receptor agonist)-induced Weight Loss by Preserving Lean Mass | Regeneron Pharmaceuticals Inc
Some users describe feeling slightly nauseous, particularly during initial doses