Therefore, it is highly likely that SR18 will be able to produce the desired agonistic effect by binding to the GLP-1R under experimental conditions
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This discovery was followed by the development of more potent peptide ligands, such as GH-releasing peptide-6, in the early 1980s to enhance GH-releasing activity in vivo (Table 1) (Cheng et al., 1993
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Tajouri L, Ovcaric M, Curtain R, Johnson MP, Griffiths LR, Csurhes P, Pender MP, Lea RA