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While targeting the gut microbiota to alleviate neuroinflammation has become an integral component of perioperative care, future investigations elucidating the molecular mechanisms underlying gut microbiota modulating neuroinflammation may be necessary for the discovery of novel drug targets for PND

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Kidd MT, Gilbert J, Corzo A, Page C, Virden WS, Woodworth JC

Glushkova, M

Adjunct exosomes and secretomes: Pairing Muse cells with exosomes and secretome components may amplify paracrine signaling, improve anti-inflammatory effects, and coordinate tissue remodeling

None of that prevents melanocortin receptor pharmacology being a legitimate field, and MC1R signalling in cultured melanocytes is a reasonable thing to study