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Sequence Modified IGF-1 (N-terminal extension + Arg3 substitution) Molecular weight 9120 Da Mechanism ~3 free fraction vs native IGF-1

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Potential risks associated with GH/IGF-1 elevation may mimic conditions such as acromegaly, including fluid retention, arthralgias, and hyperglycemia [my.clevelandclinic.org]

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Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial