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FIGURE 5 Dynamin related protein 1 (DRP1), the main mediator for mitochondrial fission, is recruited into OMM by its receptors, such as mitochondrial fission 1 protein (FIS1), mitochondrial fission factor (MFF) and mitochondrial dynamics proteins of 49 (MiD49) and 51

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This process forms a hypoxia, oxidative stress and inflammation triad, which is a vicious cycle of neuronal activation, leading to systemic brain dysfunction (39, 40)

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The livers detoxification process occurs in two main phases

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