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It is rich in nutritional elements such as Ca, Fe, and Mn, which are of great importance in the diet of people as consuming 100 g of spinach contains higher concentrations of magnesium, potassium, and iron, and separately provides 20%, 16%, and 15% of their recommended dietary intake 4

10.1016/j.canlet.2013.08.002 178 NamwanN.SenawongG.PhaosiriC.KumboonmaP.SomsakeesitL.-o.SamankulA.et al (2022)

Consequently, OCR is then represented by the R 2 reaction flux, as shown in Equation (6)

In the kidney, elevated ROS levels contribute to pathological changes such as glomerulosclerosis, tubular atrophy, and interstitial fibrosis, primarily through the activation of pro-inflammatory and pro-fibrotic signaling pathways, such as NF-B and TGF- (71)

Factors such as convenience, cost savings, potential digestive absorption issues, and comfort with self-administering injections can influence patients preferences