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10.1038/s41467-024-51079-1 Nat Commun
Wang, L., Shi, H., Zhang, X., Zhang, X., Liu, Y., Kang, W
Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ
Its C18 di-acid side-chain attachment provides enhanced albumin binding and 89% subcutaneous bioavailability, resulting in sustained therapeutic levels for approximately 14 days following discontinuation [24]
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It discusses the success of bremelanotide (derived from Melanotan II research) in later clinical trials for female sexual interest/arousal disorder, highlighting how the core mechanism identified with Melanotan II was refined into a more selective and tolerable drug for a specific indication
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