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I have already started reducing portion sizes and eating more slowly to prepare for the appetite changes." That level of specificity demonstrates genuine commitment and makes your doctor more confident in the treatment plan

It becomes difficult in some articles where he speculates on certain claims which seem entirely unsupported

JAMA , 284(7), 861-868

So if retatrutide eventually reaches market, the conversation will not just be it works better. It will also be: how much better, for whom, at what dose, and with what tolerability tradeoff