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ADMINISTRATION: Intramuscular, intravenous or subcutaneous

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Like AEDs, none of these treatments have undergone evaluation for efficacy in treating seizures within the ASD population

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Secondly, hyperglycemia-driven mitochondrial dysfunction promotes the accumulation of the TCA cycle intermediate succinate, which inhibits prolyl hydroxylases (PHDs) and stabilizes HIF-1, a master transcriptional regulator that enhances the expression of IL-1 and other M1-associated inflammatory mediators, creating a feed-forward inflammatory loop (Tannahill et al., 2013

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