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Since the average cavalier King Charles spaniel (CKCS), with no heart enlargement whatsoever, has a VHS significantly higher than 10.5 (some as high as 11.7), then following the EPIC Study investigators' VHS parameter would put a substantial number of healthy cavaliers at serious risk of heart damage (because that is what pimobendan can do to healthy dogs which do not need it)

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Therefore, the difference between this study and that of Darsalia et al

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