Indeed, a mouse model of impaired (gene knockout) BCAA catabolism showed that accumulation of BCAAs or their intermediate metabolites (branched-chain -keto acids, BCKAs) in the heart suppressed glucose metabolism by decreasing glucose uptake and mitochondrial pyruvate utilization, a key step of glucose oxidation, and promoted fatty acid oxidation 72,74,75
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DOI: 10.3928/01477447-20120222-08 Vanderah TW (2024): Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs