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10.1016/j.fertnstert.2021.07.014 6 AliA

Structural Modification 3: C18 Fatty Diacid Lipidation The Mechanism of Half-Life Extension The most consequential structural modification in cagrilintide -- and the one that defines it as a "long-acting" analog -- is the attachment of a C18 fatty diacid chain via a structured hydrophilic linker

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Advances in delivery technologies, particularly lipid nanoparticles (LNPs), have significantly improved RNA stability, targeting, and intracellular uptake