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The first prospective controlled study (compared to high-dosage L-Carnitine) showed superiority of PLUSFORTIL composition: Significantly superior to mono-preparation in regards to effect on sperm density, overall progressive and fast progressive motility Improves likelihood of successful natural and ART conception, pregnancy and offspring health PREGNANCY RATE AVG

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Consequently, both DM-succinate and ITA decreased AMPK and YBX1 protein levels in a dose-dependent manner (Extended Data Fig

However, clinical translation remains challenging, with key issues including dose optimization, safety evaluation, and patient selection