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Building on this, Ward and colleagues also showed that mutation of other solvent-exposed amino acids surrounding I253 in mouse IgG1 could result in enhanced affinity at pH 6.0 towards a truncated soluble form of mouse FcRn as measured by surface plasmon resonance (SPR), resulting in increased serum persistence in WT mice [99]
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Moderate alcohol consumption is defined as no more than 2 drinks/day for men and no more than 1 drink/day for women
AOD 9604 targets fat cells directly through beta-3 adrenergic receptor activation
After treatment cessation at week 26, some weight regain was observed by the week 32 follow-up visit
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