To explore the causes of the more severe lipid oxidation in HOMO mice, we then measured the levels of glutathione peroxidase 4 (GPX4) and acyl-CoA synthetase long-chain family member 4 (ACSL4), which protect lipids and accelerate lipid oxidation, respectively, in ferroptosis 24,25,26
The intention is that these test methods can ultimately be proposed as draft TGs, to be included in IATAs and ultimately define approaches, when fully validated in the future
10.1021/jm301191p 184 SikderM
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