Sources While glucagon-like peptide-1 (GLP-1) receptor agonists are effective for weight loss, they may also be associated with a reduction in muscle mass
Orforglipron, a novel non-peptide oral daily glucagon-like peptide-1 receptor agonist as an anti-obesity medicine: A systematic review and meta-analysis

Key Messages Intestinal paracellular permeability accounts for the movement of ions and small solutes between the intestinal lumen and the circulation through intercellular tight junctions Studies of the intestinal paracellular transport of large molecules, particulates, and bacteria investigated in cultured epithelially derived cells have to a large extent not been replicated in living organisms Intestinal permeability implying transport through intercellular tight junctions is only one component of the intestinal barrier. The two terms should be used precisely and not interchangeably Many exotoxigenic pathogenic enteric bacteria disrupt the structure and function of the tight junctions, resulting in massive fluid secretion and diarrhea It is unlikely that endotoxin enters the circulation via the paracellular route in undamaged intestinal mucosa M-cells are the most probable entry point of luminal bacteria into the submucosal lymphatics The common assumption that bacterial endotoxins or intact bacteria are transported through the intestine via the paracellular pathway in health or disease is not supported by data obtained in vivo or in vitro in intact mucosa The concept of the leaky gut should be broadened to encompass pathways other than paracellular permeability in the genesis of diseases attributed to endotoxemia References Nagpal R, Yadav H

Emotional Eating Triggers Returning For many, GLP-1s helped take the emotional edge off food decisions by minimizing cravings and reducing reward-based eating
Third, the matching methods adopted in this study mimicked a randomized controlled trial, which provides a higher level of evidence
Evaluation of condition of your cat decides dose and duration of therapy