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Piperazinopyrrolidine Analogs In a study by Ram Najar Kushwaha et al., a range of compounds was synthesized, among which 1-(2-(4-(7-chloro-4-quinolyl) piperazin-1-yl) acetyl) pyrrolidine (compound 23) was identified as a DPP-4 inhibitor (100)

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Its table calls the combination usually contraindicated and says discontinuation is recommended, which makes it the strongest warning anywhere in the article's interaction list