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Zisman, David L

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Overall, phosphorylation of NRF2, as a dynamic and reversible protein modification, is important for the regulation of signaling and biological processes inside and outside the cell (Table 1)

Thirdly, PROTAC can overcome the accessive drug resistance caused by mutation or overexpression by completely removing the pathogenic proprotein instead of blocking it for a short time [3, 11, 23,24,25,26,27]

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Cadmium-induced kidney dysfunction in our study was most likely the consequence of oxidant/antioxidant imbalance in the kidney, since it was parallel with elevated LPO and NO levels, which could be regarded as signals of increased generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS)