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While these medications are highly effective, GLP-1 side effectsespecially gastrointestinal issuescan lead to early discontinuation if not properly addressed
Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial
7 Based on this and other evidence, 8 the CADTH Canadian Drug Expert Committee recommended in 2019 that SEM should be reimbursed for adult patients with T2DM with inadequate glycemic control