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At its core dementia results from a combination of diminished synaptic connectivity among neurons and neuronal death in the entorhinal cortex, hippocampus and neocortex

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Strong signaling bursts is expected to promote cell proliferation, weaker signaling to foster differentiation, and moderate/weak signal strength in aging may be associated with neurodegenerative diseases

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(127) have shown that circulating IGF-I levels are related to the histological stages of MASLD