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Eli Lilly holds the licence for tirzepatide and supplies Mounjaro across the UK under regulation by the Medicines and Healthcare products Regulatory Agency (MHRA)

Some features of PWS, such as abnormalities in thermoregulation and sleep control and altered perception of pain indicates altered ANS

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Tramadol is indicated and effective in the treatment of moderate to severe pain 3 but not effective for severe pain, when stronger opioids should be used

Psychiatry 85 , 840844 (2014)

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