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Patients with asthma represent a relative contraindication group, as bronchospasm has been reported in susceptible individuals following parenteral administration

Possible side effects may include injection site pain, redness, allergic reactions, nausea, dizziness, or headaches

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How Estrogen Suppresses DAO, Your Histamine Cleanup Crew At the same time that estrogen pushes mast cells to release histamine, it also suppresses diamine oxidase (DAO), the primary enzyme responsible for breaking down histamine in the gut and bloodstream