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MNT had the opportunity to speak with Laurie Glasser, MD, a physical medicine and rehabilitation physician at Hackensack Meridian Healths Jersey Shore University Medical Center in New Jersey, as to why GLP-1 use might be linked to a higher risk for osteoporosis, gout, and osteomalacia in people with type 2 diabetes and obesity

2.9 Gut microbiome alteration There is still much controversy as to what constitutes a healthy microbiome and it is difficult to classify bacteria as either good or bad

The isoform of this enzyme (PI3K) is also involved in insulin signaling, and the inhibition of this pathway by either pan-PI3K inhibitors (i.e., copanlisib and duvelisib) or specific PI3K inhibitors (i.e., alpelisib and inavolisib) can lead to hyperglycemia (250)

- Increases energy, allowing for increased exercise