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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Some studies have found tirzepatide can be more effective for weight loss than regular semaglutide shots

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Cell Stem Cell 30 , 16741691.e1678 (2023)

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