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As aromatase mediates estrogen production, its inhibition with chemical molecules is considered an effective treatment for estrogen receptor (ER)-positive breast cancer

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Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow

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At the same time, maintaining robust glutathione defenses in non-tumor tissues remains a priority to protect normal cells from oxidative injury