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Proteomic and oxidative stress analysis in human brain samples of Huntington disease

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A key translational challenge will be to define the threshold and heterogeneity of GSH abundance across tumor types and microenvironmental niches, as this may critically influence treatment selectivity and resistance

Notably, glutathione balance and GPX4 levels are deeply involved in the susceptibility of cardiomyocytes to ferroptosis, a novel form of cell death

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