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A near-maximal liver fat reduction of approximately 75% was achieved coincident with an approximately 20% reduction in body weight

GLP-1s are the first drug to be FDA-approved for the treatment of sleep apnea

In July 2023, a new potential safety risk was identified associated with the GLP-1 receptor agonists exenatide, lixisenatide, liraglutide, dulaglutide and semaglutide, and the risk of suicidal thoughts and self-harm following an initial review of post-marketing reports

These benefits appear to exceed what would be expected from glucose lowering alone, suggesting additional protective mechanisms

Silveira et al

Employers must immediately explore implementation of non-traditional PBM models offered by incumbents and innovators alike, which focus on increased transparency and reduced reliance on rebates