This enzymes function extends to various tissues, making it indispensable for overall health
The presence of DHODH in mitochondria and its capacity to neutralize lipid peroxides support its protective role against ferroptosis, while DHODH deficiency has been demonstrated to induce ferroptosis [71]
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Nature 548 , 592596 (2017)
But systemic and deep dermal effects require systemic delivery
Kobayashi T, Consoli U, Andreeff M , Shiku H, Reed J, Owen-Schaub L, Deisseroth A, Zhang W
