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doi: 10.3389/fphar.2020.00886 Received 18 December 2019 Accepted 29 May 2020 Published 16 June 2020 Volume 11 - 2020 Edited by Bjorn Johansson, Karolinska Institutet (KI), Sweden Reviewed by Chieh-Hsin Lin, Kaohsiung Chang Gung Memorial Hospital, Taiwan

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Significant symptom reduction typically occurs after 6-8 weeks of consistent treatment