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Li Y, Xiao B, Qiu W, Yang L, Hu B, Tian X, et al

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

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Such cellular and biological activities of PQQ make it a potential and attractive therapeutic drug molecule to cure certain aging associated and metabolism linked diseases (Zhang et al., 2015)

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One documented case described a researcher who, after 1.5 weeks, noticed dramatic improvement, and by week 4 could perform a kneeling-to-handstand transition without the shoulder pain that had previously made this impossible