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The Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE) study demonstrated significant improvement in renal outcomes with canagliflozin in patients with T2DM and advanced macro-albuminuric kidney disease, as compared to placebo [63]

Gastrointestinal Effects GLP-1 medications have significant effects on the digestive system: They slow stomach emptying, increasing feelings of fullness They reduce gastric acid production They may help with inflammatory bowel diseases They enhance gut barrier protection They have anti-inflammatory effects in the digestive tract While these effects help with weight loss and blood sugar control, they can also cause side effects like nausea, vomiting, and diarrhea

Wegovys pricing structure may work out better for your budget, particularly if you plan to stay on treatment long-term

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