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doi: 10.3390/antiox11122336

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In a renal proximal tubule-specific Tsc1 gene-knockout mouse model, downregulated AMPK phosphorylation was observed in the enlarged kidneys, which also exhibited aberrant proliferation of proximal tubule cells, renal interstitial inflammation, and fibrosis

Freeman and Co, New York, p179

Animal studies show this mechanism reduces healing timelines by 4060% compared to controls, though no human trials validate these findings

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