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To find the best concentration levels, formulators should look at relevant clinical literature and think about doing dose-response studies while the product is being developed

We found that autophagy is activated in RGCs, and possibly also in displaced amacrine cells, in EAAC1 and GLAST KO mice, and NAC treatment suppresses autophagy only in EAAC1 KO mice

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The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance

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