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Pelegrini BL, R F, de Oliveira MM, Fernandes T, de Oliveira JH, Oliveira Junior AG, et al

175 C-Myc also regulates SIRT1 activity by inducing NAMPT expression and inhibiting BDC1

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Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury