The N-terminal methionine oxidizes, creating methionine sulfoxide that alters binding kinetics
Low Side Effects: Generally considered safe with minimal side effects, primarily skin whitening with high doses
In Vitro GSH Skin Permeation Tests To investigate the ex vivo permeation kinetics across the skin of the reduced-GSH released from the GSH 2.5 -HA MN patches, static diffusion Franz cell tests were performed to calculate the rate of time-dependent GSH release through GSH 2.5 -HA MNs and its diffusion through the skin along with a reference GSH-HA solution
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de Queiroz TM, Xia H, Filipeanu CM, Braga VA, Lazartigues E
Planta Med 1998;64(4):353356