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Structural and molecular basis for mitochondrial DNA replication and transcription in health and antiviral drug toxicity

GLP-1RAs are overall well-tolerated, with their most common adverse effects being nausea, vomiting, and diarrhea [7]

This may explain the hepatotoxic potential of this VPA metabolite and the development of liver failure in patients with a deficiency in the mitochondrial DNA replicase system, such as gamma polymerase [115]

Prior to initiating VYVANSE treatment, screen patients for risk factors for developing a manic episode (e.g., comorbid or history of depressive symptoms or a family history of suicide, bipolar disorder, and depression)

Take note of any changes in size, colour, or associated symptoms

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